According to Syrian new sources on Tuesday, the strike was launched on the government-held region of Qusur.
"Twenty two civilians were dead and more than 30 others injured in air strikes by coalition planes on the Al-Qusor neighborhood in Dayr al-Zawr city," one of the sources said.
Read more: US has wiped Raqqah off the face of earth: Russia
The so-called Syrian Observatory for Human Rights puts the death toll at around 22 without confirming the origin of the strikes.
The US-led coalition has been conducting airstrikes against what are said to be Daesh targets inside Syria since September 2014 without any authorization from the Damascus government or a UN mandate.
The military alliance has repeatedly been accused of targeting and killing civilians. It has also been largely incapable of achieving its declared goal of destroying Daesh.
Also read: Syrian army troops, allies liberate central town in Homs from Daesh
The US-led air raids also resulted in the injury of hundreds of civilians, some of whom suffered permanent disabilities and had to have their limbs amputated.
The aerial raids caused massive destruction of residential buildings and civilian infrastructure as well.
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